MECHANISM OF DISEASE
TSLP CAN DRIVE AIRWAY INFLAMMATION
AND CONTRIBUTE TO AIRWAY HYPERRESPONSIVENESS1
See the important role TSLP plays at the top of the inflammatory cascade1-3
Unpredictable Triggers
Patients can have multiple environmental triggers, and the airway epithelium is the first point of contact for these triggers1-3
Airway Hyperresponsiveness
Airway Inflammation
TSLP
TSLP is primarily released by the epithelial cells in response to environmental triggers1-4
TSLP
TSLP is primarily released by the epithelial cells in response to environmental triggers1-4
Complex Pathways
TSLP can activate multiple downstream pathways that can drive airway inflammation and contribute to airway hyperresponsiveness1-4
Complex Pathways
TSLP can activate multiple downstream pathways that can drive airway inflammation and contribute to airway hyperresponsiveness1-4
FeNO=fractional exhaled nitric oxide;
IgE=immunoglobulin E; IL=interleukin;
TSLP=thymic stromal lymphopoietin.
Target what many patients with severe asthma have in common: TSLP1-3,5
Unpredictable Triggers
Patients can have multiple environmental triggers, and the airway epithelium is the first point of contact for these triggers1-3
Target what many patients with severe asthma have in common: TSLP1-3,5
“Please refer to the important safety information on the Main Tezspire page.”
References: 1. Gauvreau GM, Sehmi R, Ambrose CS, Griffiths JM. Thymic stromal lymphopoietin: its role and potential as a therapeutic target in asthma. Expert Opin Ther Targets. 2020;24(8):777-792. 2. Lambrecht BN, Hammad H, Fahy JV. The cytokines of asthma. Immunity. 2019;50(4):975-991. 3. Lambrecht BN, Hammad H. The immunology of asthma. Nat Immunol. 2015;16(1):45-56. 4. Brusselle GG, Maes T, Bracke KR. Eosinophils in the spotlight: eosinophilic airway inflammation in nonallergic asthma. Nat Med. 2013;19(8):977-979. 5. TEZSPIRE® (tezepelumab-ekko) [package insert]. Thousand Oaks, CA: Amgen Inc.; and Wilmington, DE: AstraZeneca Pharmaceuticals LP; February 2023.