EOSINOPHILIC INFALMMATION
ACROSS INFLAMMATORY DISEASESEOSINOPHILIC ESOPHAGITIS (EoE)
EOSINOPHILIC ESOPHAGITIS (EoE)
WHAT IS EOSINOPHILIC ESOPHAGITIS (EoE)?
Eosinophilic esophagitis (EoE) is a chronic, inflammatory disorder of the esophagus characterized by eosinophilic inflammation and symptoms related to esophageal dysfunction.1-3
Symptoms associated with eosinophilic esophagitis include1,2,4,5:
- Dysphagia
- Upper abdominal pain
- Chest pain
- Painful swallowing
- Food impaction
Incidence6,7
Approximately 1-20 new cases per
100,000 people per year
Estimated Prevalence8
22.7 cases per 100,000
(95% CI 12.4-36.0)
THE ROLE OF EOSINOPHILIC INFALMMATION IN EOSINOPHILIC ESOPHAGITIS
Dysregulated immune responses lead to the recruitment and activation of eosinophils,
potentially causing eosinophilic inflammation and symptoms associated with
esophageal dysfunction.9-11
Adapted from O’Shea KM, et al. Gastroenterology. 2018.9
IMPACT OF EOSINOPHILIC ESOPHAGITIS ON PATIENTS
Eosinophilic esophagitis is a lifelong, progressive disease that can significantly impact patients’ quality of life.5,8,12
ASTRAZENECA IS COMMITTED TO UNCOVERING THE ROLE OF EOSINOPHILIC INFALMMATION IN EOSINOPHILIC ESOPHAGITIS.
References: 1. Liacouras CA, Furuta GT, Hirano I, et al. Eosinophilic esophagitis: updated consensus recommendations for children and adults. J Allergy Clin Immunol. 2011:128(1):3-22. 2. Carr S, Chan ES, Watson W. Eosinophilic esophagitis. Allergy Asthma Clin Immunol. 2018;14(Suppl 2):58. 3. Gonsalves N. Clinical presentation and approach to dietary management of eosinophilic esophagitis. Gastroenterol Hepatol (N Y). 2018;14(12):706-712. 4. Hirano I, Furuta GT. Approaches and challenges to management of pediatric and adult patients with eosinophilic esophagitis. Gastroenterology. 2020;158(4):840851. 5. Safroneeva E, Coslovsky M, Kuehni CE et al. Eosinophilic oesophagitis: relationship of quality of life with clinical, endoscopic and histological activity. Aliment Pharmacol Ther. 2015; 42(8):1000-1010. 6. Lucendo AJ, Molina-Infante J, Arias Á, et al. Guidelines on eosinophilic esophagitis: evidence-based statements and recommendations for diagnosis and management in children and adults. United European Gastroenterol J. 2017;5(3)335-358. 7. Moawad FJ. Eosinophilic esophagitis incidence and prevalence. Gastrointest Endosc Clin N Am. 2018;28(1)15-25. 8. Dellon ES, Hirano I. Epidemiology and natural history of eosinophilic esophagitis. Gastroenterology. 2018;154(2):319-332.e3. 9. O’Shea KM, Aceves SS, Dellon ES, et al. Pathophysiology of eosinophilic esophagitis. Gastroenterology. 2018;154(2):333-345. 10. Doherty TA, Baum R, Newbury RO, et al. Group 2 innate lymphocytes (ILC2) are enriched in active eosinophilic esophagitis. J Allergy Clin Immunol. 2015;136(3):792-794.e3. 11. Chen JW, Kao JY. Eosinophilic esophagitis: update on management and controversies. BMJ. 2017;359:j4482. 12. Dellon ES, Kim HP, Sperry SL, et al. A phenotypic analysis shows that eosinophilic esophagitis is a progressive fibrostenotic disease. Gastrointest Endosc. 2014;79(4):577-585.e4.